Activate FOXO3 — The Gene That Helps You Age Well Written by: Clement Ng, Nutritionist of HealthProIntroductionGeroprotectors, compounds that act to slow down the aging process and delay the onset of age-related diseases, have emerged as means to prolong healthspan in the aging population (Alexey Moskalev, 2016). Central to these geroprotectors is FOXO3, a geroprotective gene that has been consistently associated with human longevity (Robert N. Butler MD, 2013). Studies have shown FOXO3 to play an essential role to slow down aging by being a significant regulator of cellular stress..